Pair Name	Aloin, Irinotecan
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	IGF1R	hsa3480
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
In Vitro Model	LoVo	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0399
In Vivo Model	4×10⁶ LoVo cells were suspended in serum-free Matrigel medium.Control (DMSO), CPT-11(2 mg/Kg), Aloin (20 mg/Kg), and combination (2 mg/Kg CPT-11 + 20 mg/Kg Aloin). The mice were treated via intratumor injection, every 48 h for four weeks.
Result	Our findings suggests that CPT-11 and Aloin are potential combination treatment partners against colorectal cancer. MicroRNA-133b may serve as a co-therapeutic target with IGF1R against colorectal cancer, which might overcome the existing treatment limitations.